Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218709 | 0.90 | KCNH2 (0.65) | KCNH2ACHERAF1MAPK9EGFR | |
| SCHEMBL6218705 | 0.90 | KCNH2 (0.65) | KCNH2ACHERAF1MAPK9EGFR | |
| SCHEMBL5818632 | 0.90 | KCNH2 (0.65) | KCNH2ACHERAF1MAPK9EGFR | |
| SCHEMBL5818972 | 0.89 | EGFR (0.64) | KCNH2RAF1MAPK9EGFRERBB2 | |
| SCHEMBL5818421 | 0.85 | MAPK13 (0.56) | KCNH2ACHERAF1MAPK9MAPK13 | |
| SCHEMBL5813602 | 0.84 | MAPK13 (0.57) | KCNH2ACHERAF1MAPK9MAPK13 | |
| SCHEMBL5820631 | 0.84 | MAPK13 (0.55) | KCNH2ACHERAF1MAPK9MAPK13 | |
| SCHEMBL5817158 | 0.83 | KCNH2 (0.58) | KCNH2ACHE | |
| SCHEMBL5820567 | 0.83 | KCNH2 (0.50) | KCNH2MAPK9MAPK8MAPK13MAPK12 | |
| SCHEMBL5819343 | 0.83 | EGFR (0.49) | RAF1MAPK9EGFRERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |