Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | RAF1 | P04049 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218709 | 1.00 | KCNH2 (0.65) | KCNH2ACHEEGFRRAF1ERBB2 | |
| SCHEMBL5818632 | 1.00 | KCNH2 (0.65) | KCNH2ACHEEGFRRAF1ERBB2 | |
| SCHEMBL5813602 | 0.91 | MAPK13 (0.57) | KCNH2ACHERAF1MAPK9 | |
| SCHEMBL5819638 | 0.90 | KCNH2 (0.53) | KCNH2ACHEEGFRRAF1ERBB2 | |
| SCHEMBL6488022 | 0.89 | EGFR (0.76) | KCNH2EGFRRAF1ERBB2SRC | |
| SCHEMBL6488017 | 0.89 | EGFR (0.76) | KCNH2EGFRRAF1ERBB2SRC | |
| SCHEMBL5824185 | 0.88 | MAPK13 (0.51) | KCNH2ACHERAF1MAPK9 | |
| SCHEMBL5818421 | 0.86 | MAPK13 (0.56) | KCNH2ACHERAF1MAPK9 | |
| SCHEMBL5820631 | 0.86 | MAPK13 (0.55) | KCNH2ACHERAF1MAPK9 | |
| SCHEMBL5818883 | 0.85 | KCNH2 (0.79) | KCNH2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224185-B1 | THIAZOLE AND IMIDAZO[4,5-B]PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | NOVARTIS AG (CH) | 2005-11-30 | — | — | EP | disclosed |
| US-6608072-B1 | Inhibiting production of soluble tumor necrosis factor or reducing inflammation | NOVARTIS AG (CH) | 2003-08-19 | — | — | US | disclosed |