Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.43 |
| ▸ | CSK | P41240 | 4/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820505 | 0.93 | MAPK14 (0.48) | BRAFMAPTFGFR1FGFR2FGFR3 | |
| SCHEMBL5821664 | 0.91 | FGFR1 (0.48) | TP53MAPTSMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL5817149 | 0.90 | FGFR1 (0.52) | MAPTSMN1; SMN2FGFR1FGFR2FGFR3 | |
| SCHEMBL5819020 | 0.86 | MAP3K20 (0.59) | MAPTMAPK14MAP3K20MAP3K7MAP4K2 | |
| SCHEMBL5812553 | 0.84 | CHRM1 (0.53) | TP53MAPTFGFR1FGFR2FGFR3 | |
| SCHEMBL5819066 | 0.84 | KDR (0.51) | MAPTTHRBFGFR1FGFR2FGFR3 | |
| SCHEMBL5823136 | 0.82 | FGFR1 (0.57) | MAPTSMN1; SMN2FGFR1FGFR2FGFR3 | |
| SCHEMBL5814241 | 0.81 | FGFR1 (0.47) | BRAFFGFR1FGFR2FGFR3KDR | |
| SCHEMBL5819541 | 0.81 | KDR (0.54) | TP53MAPTSMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL5817693 | 0.81 | MAP4K2 (0.50) | BRAFFGFR1FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | claimed |