Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473972 | 0.77 | PRCP (0.43) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL5360614 | 0.75 | PARP1 (0.37) | HTR2A | |
| SCHEMBL4276041 | 0.72 | PRCP (0.44) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL27814188 | 0.71 | CYP1A2 (0.39) | GAAHTR2A | |
| SCHEMBL18093730 | 0.70 | CYP2D6 (0.33) | TSHRKDM4EALDH1A1MAPT | |
| SCHEMBL30399174 | 0.70 | HTR2C (0.42) | HTR2AHTR2CHTR2B | |
| SCHEMBL28294761 | 0.70 | PARP1 (0.37) | — | |
| SCHEMBL30345136 | 0.69 | PRCP (0.41) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL5571017 | 0.68 | PRCP (0.51) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL27898029 | 0.68 | HTR2C (0.39) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723134-A2 | TETRAHYDROISOQUINOLINYL DERIVATIVES OF QUINAZOLINE AND ISOQUINOLINE | Pfizer Products Incorporated (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082883-A2 | TETRAHYDROISOQUINOLINYL DERIVATIVES OF QUINAZOLINE AND ISOQUINOLINE | PFIZER PRODUCTS INC. (US) | 2005-09-09 | — | — | WO | disclosed |