Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289712 | 0.76 | AKR1C3 (0.34) | HTR2C | |
| SCHEMBL5819959 | 0.72 | PRCP (0.43) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL21821539 | 0.72 | CHRNA7 (0.46) | TSHRHTR2COPRM1 | |
| SCHEMBL5571017 | 0.69 | PRCP (0.51) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL5567920 | 0.67 | OPRM1 (0.50) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL15473972 | 0.67 | PRCP (0.43) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL24017043 | 0.66 | PRCP (0.70) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL16799768 | 0.66 | PRCP (0.70) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL30368634 | 0.66 | PRCP (0.70) | PRCPGAASLC22A1RECQLTSHR | |
| SCHEMBL10434815 | 0.66 | PRCP (0.45) | PRCPGAASLC22A1RECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |