Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820089 | 0.85 | ALDH1A1 (0.53) | CDC7DBF4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL5820220 | 0.83 | CDC7 (0.54) | CDC7DBF4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL6183101 | 0.81 | CDC7 (0.52) | CDC7DBF4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL18114028 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HPGDPOLBSMN1; SMN2KMT2A | |
| SCHEMBL5761297 | 0.76 | ADORA1 (0.59) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| SCHEMBL5820225 | 0.76 | CDC7 (0.52) | CDC7DBF4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL11286051 | 0.73 | ALDH1A1 (0.70) | CDC7DBF4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3891572 | 0.73 | PLK1 (0.48) | MAPK1CYP1A2 | |
| SCHEMBL3893366 | 0.72 | ALDH1A1 (0.44) | ALDH1A1HPGDLMNAHTTNPSR1 | |
| SCHEMBL3893334 | 0.72 | FGFR1 (0.46) | HPGDNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |