SCHEMBL5820093

SCHEMBL5820093

CCn1nccc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CETP P11597 19/20 0.40
TACR1 P25103 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5821109 0.88 CETP (0.40) CETPTACR1
SCHEMBL5140629 0.83 TACR1 (0.41) CETPTACR1
SCHEMBL5140076 0.80 CETP (0.39) CETP
SCHEMBL5822402 0.78 CETP (0.40) CETPTACR1
SCHEMBL1601013 0.78 CETP (0.45) CETPTACR1
SCHEMBL1600532 0.78 CETP (0.43) CETPTACR1
SCHEMBL4173923 0.77 TACR1 (0.42) CETPTACR1
SCHEMBL6093458 0.77 CETP (0.37) CETP
SCHEMBL13697600 0.76 CETP (0.43) CETPTACR1
SCHEMBL14416107 0.74 CETP (0.43) CETPTACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1848430-A2 NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS Reddy US Therapeutics, Inc. (US) 2007-10-31 EP claimed
WO-2006073973-A2 NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS REDDY US THERAPEUTICS, INC. (US) 2006-07-13 WO claimed
EP-1848430-A2 NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS Reddy US Therapeutics, Inc. (US) 2007-10-31 EP disclosed
WO-2006073973-A2 NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS REDDY US THERAPEUTICS, INC. (US) 2006-07-13 WO disclosed