Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823210 | 0.88 | KCNH2 (0.42) | KCNH2 | |
| SCHEMBL5815511 | 0.87 | KCNH2 (0.43) | KCNH2 | |
| SCHEMBL5818492 | 0.84 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5815503 | 0.81 | TGFBR1 (0.56) | MAPK14TGFBR1 | |
| SCHEMBL5820811 | 0.81 | ALDH1A1 (0.44) | KCNH2MAPK14TGFBR1 | |
| SCHEMBL5813401 | 0.81 | IKBKB (0.53) | KCNH2EGFRMAPK14KDRMAPK8 | |
| SCHEMBL5817588 | 0.80 | IKBKB (0.54) | KCNH2EGFRMAPK8 | |
| SCHEMBL5818273 | 0.79 | IKBKB (0.56) | KCNH2EGFRMAPK8 | |
| SCHEMBL5817783 | 0.79 | CCNT1 (0.43) | MAPK14TGFBR1 | |
| SCHEMBL5818662 | 0.78 | KCNH2 (0.44) | KCNH2EGFRMAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |