Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.67 |
| ▸ | NCF1 | P14598 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27856065 | 0.83 | CYP11B1 (0.61) | CYP11B1CYP11B2CDK8MAPT | |
| SCHEMBL27904788 | 0.83 | LRRK2 (0.57) | CYP11B1CYP11B2NCF1LRRK2KDM4E | |
| SCHEMBL31342013 | 0.83 | CYP11B1 (0.72) | CYP11B1CYP11B2NCF1CDK8KDM4E | |
| SCHEMBL15488697 | 0.81 | POLB (0.52) | CYP11B1CYP11B2KDM4EMAPTPOLB | |
| SCHEMBL28033595 | 0.80 | CYP11B1 (0.61) | CYP11B1CYP11B2NCF1CDK8 | |
| SCHEMBL6263602 | 0.80 | CYP11B1 (0.66) | CYP11B1CYP11B2NCF1CDK8KDM4E | |
| SCHEMBL2320577 | 0.79 | NCF1 (0.62) | NCF1KDM4EMAPTPOLBPRKDC | |
| SCHEMBL29999231 | 0.79 | NCF1 (0.62) | NCF1KDM4EMAPTPOLBPRKDC | |
| SCHEMBL15741641 | 0.76 | PIK3CA (0.48) | CYP11B1CYP11B2PRKDCMETAP1 | |
| SCHEMBL6359045 | 0.75 | CYP11B1 (0.60) | CYP11B1CYP11B2NCF1CDK8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |