⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820437 | 0.82 | MAP4K4 (0.41) | — | |
| SCHEMBL2901836 | 0.81 | PDE4D (0.37) | — | |
| SCHEMBL2901841 | 0.80 | VCP (0.43) | — | |
| SCHEMBL2901839 | 0.80 | VCP (0.43) | — | |
| SCHEMBL2908190 | 0.67 | PDE4D (0.42) | — | |
| SCHEMBL2908809 | 0.67 | PDE4D (0.33) | — | |
| SCHEMBL2909161 | 0.67 | PDE4D (0.33) | — | |
| SCHEMBL2903176 | 0.67 | PDE4D (0.44) | — | |
| SCHEMBL2905403 | 0.67 | PDE4D (0.44) | — | |
| SCHEMBL2903089 | 0.67 | PDE4A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-A2 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | Memory Pharmaceuticals Corporation (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005061458-A2 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |