Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822743 | 0.72 | SMN1; SMN2 (0.33) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL1787392 | 0.65 | NOTUM (0.42) | LMNAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1788065 | 0.64 | RAB9A (0.41) | LMNAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1785591 | 0.63 | TNK2 (0.43) | RAB9ANPC1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL17961876 | 0.62 | NPBWR1 (0.44) | HPGD | |
| SCHEMBL5814421 | 0.62 | GRM1 (0.52) | KDM4E | |
| SCHEMBL1784417 | 0.62 | PARP1 (0.37) | LMNAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13946364 | 0.61 | SMN1; SMN2 (0.42) | LMNAMAPTSMN1; SMN2GAAKDM4E | |
| SCHEMBL14501809 | 0.59 | PDE9A (0.46) | LMNAMAPTHPGDALDH1A1PDE9A | |
| SCHEMBL22987199 | 0.57 | PDPK1 (0.41) | RAB9ANPC1SMN1; SMN2GAAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10449216-B2 | Modulating drug effects against metabotropic glutamate receptor with extracellular calcium | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20160220603-A1 | MODULATING DRUG EFFECTS AGAINST METABOTROPIC GLUTAMATE RECEPTOR WITH EXTRACELLULAR CALCIUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2016-08-04 | — | — | US | disclosed |
| WO-2006081072-A1 | ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2006-08-03 | — | — | WO | disclosed |