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Tryptophan

Tryptophan

SCHEMBL5820703

CC(C)C[C@H](N)C(=O)Oc1ccc(C[C@H](N)C(=O)O)cc1.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](OC(=O)[C@@H](N)Cc1ccccc1)[C@H](N)C(=O)OC[C@H](N)C(=O)OC(=O)[C@@H](N)CCCNC(=N)N.C[C@H](N)C(=O)OC(=O)CN.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PTH1R Q03431 15/20 0.39
▸ GLP1R P43220 4/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL6482306 0.95 PTH1R (0.40) PTH1RGLP1R
Tryptophan SCHEMBL10623343 0.94 GLP1R (0.39) PTH1RGLP1R
Phenylalanine SCHEMBL6479234 0.91 GLP1R (0.35) PTH1RGLP1R
Arginine SCHEMBL8152157 0.91 GLP1R (0.38) PTH1RGLP1R
Tryptophan SCHEMBL10619278 0.90 GLP1R (0.41) PTH1RGLP1R
Arginine SCHEMBL6438609 0.90 PTH1R (0.41) PTH1RGLP1R
Tryptophan SCHEMBL9295342 0.90 PTH1R (0.40) PTH1RGLP1R
Phenylalanine SCHEMBL6437396 0.88 GLP1R (0.34) PTH1RGLP1R
Tryptophan SCHEMBL9152334 0.88 PTH1R (0.42) PTH1RGLP1R
Tryptophan SCHEMBL9614424 0.87 PTH1R (0.39) PTH1RGLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1704242-A2 COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF The Scripps Research Institute (US) 2006-09-27 — — EP disclosed
EP-1658366-A4 COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF SCRIPPS RESEARCH INST (US) 2006-08-09 — — EP disclosed
EP-1658366-A2 COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF The Scripps Research Institute (US) 2006-05-24 — — EP disclosed
WO-2005007624-A2 COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2005-01-27 — — WO disclosed
WO-2005007870-A2 COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2005-01-27 — — WO disclosed