Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820736 | 0.80 | NAMPT (0.58) | NAMPTALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL27810270 | 0.79 | EGLN1 (0.74) | NAMPTALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL29862956 | 0.79 | EGLN1 (0.74) | NAMPTALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL4246266 | 0.78 | PKN1 (0.53) | NAMPTALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL4246271 | 0.78 | ALDH1A1 (0.53) | NAMPTALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL5480367 | 0.76 | PARP1 (0.66) | RXFP1PARP1 | |
| SCHEMBL27810327 | 0.75 | EGLN1 (0.58) | NAMPTALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL1477698 | 0.75 | PARP1 (0.69) | RXFP1PARP1 | |
| SCHEMBL29698487 | 0.75 | PARP1 (0.64) | RXFP1PARP1 | |
| SCHEMBL4241048 | 0.74 | HTR2C (0.70) | NAMPTALDH1A1KDM4EMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006130673-A1 | 3-BENZOIMIDAZOLYL-PYRAZOLOPYRIDINES USEFUL IN TREATING KINASE DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | claimed |