Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820800 | 0.80 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL5820637 | 0.72 | CNR2 (0.44) | ALDH1A1CNR2KMT2AALOX15HTT | |
| SCHEMBL2086460 | 0.64 | PTGS1 (0.50) | CNR2 | |
| SCHEMBL7573834 | 0.64 | KMT2A (0.47) | ALDH1A1CNR2KMT2AMEN1NPC1 | |
| SCHEMBL16415854 | 0.62 | KMT2A (0.53) | ALDH1A1CNR2KMT2AALOX15MEN1 | |
| SCHEMBL5604467 | 0.62 | KMT2A (0.63) | ALDH1A1CNR2KMT2AALOX15MEN1 | |
| SCHEMBL20104422 | 0.61 | KMT2A (0.56) | ALDH1A1CNR2KMT2AMEN1NPC1 | |
| SCHEMBL3117070 | 0.61 | KMT2A (0.52) | ALDH1A1CNR2KMT2AALOX15HTT | |
| SCHEMBL4243991 | 0.61 | GAA (0.59) | NPC1RAB9A | |
| SCHEMBL1728538 | 0.61 | PTGS1 (0.73) | ALDH1A1KMT2AMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006084835-A1 | N-(3-(IMIDAZO [1,5-A]PYRIMIDIN-4-YL)PHENYL]-SULFONAMIDES AND N-[3-(IMIDAZO[1,5-A]PYRIMIDIN-4-YL)-PHENYL]-CARBOXAMIDES AND THEIR USE AS GABAA RECEPTOR MODULATORS | FERRER INTERNACIONAL, S. A. (ES) | 2006-08-17 | — | — | WO | disclosed |