Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217488 | 0.88 | PTGS1 (0.60) | PTGS1PTGS2RAB9ANPC1MAPT | |
| SCHEMBL4225362 | 0.88 | RAB9A (0.67) | PTGS1PTGS2RAB9ANPC1MAPT | |
| SCHEMBL118449 | 0.84 | PTGS1 (1.00) | PTGS1PTGS2RAB9ANPC1MAPT | |
| SCHEMBL2334973 | 0.83 | PTGS1 (0.96) | PTGS1PTGS2RAB9ANPC1MAPT | |
| Water SCHEMBL21708935 | 0.83 | PTGS1 (0.96) | PTGS1PTGS2RAB9ANPC1MAPT | |
| Bromide SCHEMBL570786 | 0.83 | PTGS1 (0.96) | PTGS1PTGS2RAB9ANPC1MAPT | |
| Hydrochloric Acid SCHEMBL8878519 | 0.83 | PTGS1 (0.96) | PTGS1PTGS2RAB9ANPC1MAPT | |
| SCHEMBL1728496 | 0.83 | PTGS1 (0.50) | PTGS1PTGS2RAB9ANPC1MAPT | |
| SCHEMBL2087427 | 0.81 | PTGS1 (0.49) | PTGS1PTGS2RAB9ANPC1MAPT | |
| SCHEMBL2085892 | 0.81 | RAB9A (0.50) | PTGS1PTGS2RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262805-B1 | POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYL-IMIDAZO[L,2-A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-10-22 | — | — | EP | disclosed |
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | disclosed |
| EP-2260033-B1 | 2-benzoylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | SANOFI SA (FR) | 2011-11-23 | — | — | EP | disclosed |
| EP-2260033-B1 | 2-benzoylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | SANOFI SA (FR) | 2011-11-23 | — | — | EP | disclosed |
| EP-2225245-B1 | N-phenyl-imidazo(1,2-a)pyridine-2-carboxamide compounds, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-10-19 | — | — | EP | disclosed |
| US-20100317620-A1 | N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE COMPOUNDS, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | disclosed |
| US-20100317687-A1 | 2-BENZOYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | disclosed |
| US-20100317687-A1 | 2-BENZOYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | disclosed |
| US-20100317688-A1 | 2-HETEROAROYLIMIDAZOL[1,2-a]PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | disclosed |
| CN-101910174-A | 2-benzoylimidazo [1,2-a ] pyridine derivatives, preparation thereof and therapeutic use thereof | SANOFI AVENTIS | 2010-12-08 | — | — | CN | disclosed |
| EP-2040703-B1 | DERIVATIVES OF 2-BENZOYL-IMIDAZOPYRIDINES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2009-10-21 | — | — | EP | disclosed |
| US-20090143421-A1 | USE OF 2-BENZOYL-IMIDAZOPYRIDINES IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-06-04 | — | — | US | disclosed |
| US-4352804-A | ANTIULCER AGENTS, GASTROINTESTINAL DISORDERS | ACF CHEMIEFARMA NV (NL) | 1982-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317688-A1 | 2-HETEROAROYLIMIDAZOL[1,2-a]PYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | XDH, CYP11B2, IL4I1 | PTGS1 742/4885PTGS2 846/4885RAB9A 1356/4885 |
| US-20100317687-A1 | 2-BENZOYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | XDH, REN, GLS | PTGS1 1046/4885PTGS2 1343/4885RAB9A 1587/4885 |
| US-20100317620-A1 | N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE COMPOUNDS, PREPARATION AND THERAPEUTIC USE THEREOF | GLS, REN, XDH | PTGS1 1688/4885PTGS2 1923/4885RAB9A 1438/4885 |
| US-20090143421-A1 | USE OF 2-BENZOYL-IMIDAZOPYRIDINES IN THERAPEUTICS | NCOR1, NR4A3, NR4A2 | PTGS1 2541/4885PTGS2 2339/4885RAB9A 3315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.