Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5821680 | 1.00 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPC1LMNAMAPK1 | |
| SCHEMBL5823344 | 0.73 | KAT2B (0.42) | ALDH1A1LMNAHTTMAPTMEN1 | |
| SCHEMBL1134969 | 0.68 | PRKCI (0.44) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL22025941 | 0.66 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2NPC1LMNAMAPK1 | |
| SCHEMBL15555902 | 0.66 | FGFR1 (0.42) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL15555901 | 0.66 | FGFR1 (0.42) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL26220089 | 0.66 | PRKCI (0.61) | JAK2JAK1JAK3AXLPRKCI | |
| SCHEMBL18926217 | 0.65 | PRKCI (0.44) | JAK2JAK1JAK3AXLPRKCI | |
| SCHEMBL11494910 | 0.64 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2NPC1LMNAMAPK1 | |
| SCHEMBL17495401 | 0.62 | PRKCI (0.46) | ALDH1A1SMN1; SMN2NPC1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006124731-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-11-23 | — | — | WO | disclosed |