Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.41 |
| ▸ | RASGRP3 | Q8IV61 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822258 | 1.00 | MAPT (0.54) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822401 | 0.91 | MAPT (0.56) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822395 | 0.91 | MAPT (0.56) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822192 | 0.86 | KMT2A (0.52) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822188 | 0.86 | KMT2A (0.52) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822238 | 0.81 | MAPT (0.46) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822245 | 0.81 | MAPT (0.46) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822419 | 0.81 | MAPT (0.47) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5822424 | 0.81 | MAPT (0.47) | MAPTNPSR1HTTLMNAPTK2B | |
| SCHEMBL5820835 | 0.78 | ALDH1A1 (0.57) | MAPTNPSR1HTTLMNAPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |