Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | RASGRP3 | Q8IV61 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822188 | 1.00 | KMT2A (0.52) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822258 | 0.86 | MAPT (0.54) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822263 | 0.86 | MAPT (0.54) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822521 | 0.84 | KMT2A (0.60) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822520 | 0.84 | KMT2A (0.60) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5821804 | 0.80 | DHFR (0.64) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5821802 | 0.80 | DHFR (0.64) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822401 | 0.78 | MAPT (0.56) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822395 | 0.78 | MAPT (0.56) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL5822245 | 0.74 | MAPT (0.46) | KMT2AMEN1MAPTNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | claimed |
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |