Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569479 | 0.90 | MAPT (0.43) | MAPTKDM4ELMNAHTTTHRB | |
| SCHEMBL5822984 | 0.83 | MAPT (0.38) | MAPTKDM4ELMNAHTTTHRB | |
| SCHEMBL3566847 | 0.82 | MAPT (0.35) | MAPTKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3570706 | 0.82 | F10 (0.40) | MAPTKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3573941 | 0.80 | SMN1; SMN2 (0.34) | MAPTKDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3569482 | 0.79 | RAB9A (0.42) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL3561242 | 0.73 | F10 (0.39) | MAPTKDM4ETHRBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3565023 | 0.71 | F10 (0.43) | MAPTKDM4EALDH1A1TDP1 | |
| SCHEMBL3570709 | 0.71 | HTT (0.42) | MAPTLMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3566849 | 0.71 | HTT (0.41) | MAPTLMNAHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006063113-A2 | UREAS AS FACTOR XA INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |