Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALAD | P13716 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823015 | 0.79 | KMT2A (0.56) | TP53MAPK1KMT2AALOX15PTGS2 | |
| SCHEMBL9773323 | 0.79 | CES1 (0.40) | TP53MAPK1KMT2AALOX15GABRA1 | |
| SCHEMBL2122531 | 0.74 | CYP2A6 (0.58) | MAPK1KMT2ACYP2A6PTGS2ALDH1A1 | |
| SCHEMBL21067334 | 0.73 | APP (0.43) | TP53MAPK1KMT2AALOX15ALDH1A1 | |
| SCHEMBL15695234 | 0.73 | KMT2A (0.50) | TP53MAPK1KMT2AALOX15ALDH1A1 | |
| SCHEMBL16049288 | 0.70 | PTGS1 (0.46) | TP53MAPK1KMT2AALOX15PTGS2 | |
| SCHEMBL1548500 | 0.70 | — | — | |
| SCHEMBL3128189 | 0.69 | MAPT (0.41) | TP53MAPK1KMT2AALOX15CYP2A6 | |
| SCHEMBL15972026 | 0.69 | NEK2 (0.34) | TP53MAPK1KMT2AALOX15ALDH1A1 | |
| SCHEMBL3127775 | 0.69 | PGR (0.44) | MAPK1CYP2A6ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155004-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-12-18 | — | — | US | disclosed |
| US-9717739-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-08-01 | — | — | US | disclosed |
| US-20170202857-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-20 | — | — | US | disclosed |
| US-20150342962-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER IP GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-8278469-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20120149670-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-14 | — | — | US | disclosed |
| US-20120094969-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155004-B2 | 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | CYP19A1, SHBG, HSD17B11 | TP53 1119/4885MAPK1 3898/4885KMT2A 1334/4885 |
| US-20170202857-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | TP53 1119/4885MAPK1 3898/4885KMT2A 1334/4885 |
| US-20150342962-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | TP53 1119/4885MAPK1 3898/4885KMT2A 1334/4885 |
| US-20120094969-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | TP53 1119/4885MAPK1 3898/4885KMT2A 1334/4885 |
| US-20120149670-A1 | 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHOD OF PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF DISEASES | CYP19A1, SHBG, HSD17B11 | TP53 1119/4885MAPK1 3898/4885KMT2A 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.