Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 11/20 | 0.38 |
| ▸ | DRD3 | P35462 | 11/20 | 0.38 |
| ▸ | DRD4 | P21917 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917599 | 0.79 | CHEK1 (0.52) | HRH4HRH3CHEK1DRD2DRD3 | |
| SCHEMBL5793647 | 0.78 | HRH4 (0.47) | HRH4HRH3CHEK1DRD2DRD3 | |
| SCHEMBL5917611 | 0.74 | CHEK1 (0.46) | HRH4HRH3CHEK1KDM4EALDH1A1 | |
| SCHEMBL5917666 | 0.73 | HRH4 (0.40) | HRH4HRH3CHEK1DRD2DRD3 | |
| SCHEMBL27754149 | 0.73 | CHEK1 (0.42) | HRH3CHEK1HPGD | |
| SCHEMBL5793515 | 0.72 | HRH3 (0.45) | HRH4HRH3CHEK1DRD3DRD4 | |
| SCHEMBL5796117 | 0.72 | CHEK1 (0.58) | HRH4HRH3CHEK1KDM4EALDH1A1 | |
| SCHEMBL5794513 | 0.72 | DRD2 (0.46) | HRH4HRH3CHEK1DRD2DRD3 | |
| SCHEMBL5917615 | 0.72 | HRH3 (0.52) | HRH4HRH3CHEK1DRD2DRD3 | |
| SCHEMBL5917635 | 0.71 | HRH4 (0.46) | HRH4CHEK1DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006035308-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-04-06 | — | — | WO | disclosed |