Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.42 |
| ▸ | CDK7 | P50613 | 6/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917615 | 0.77 | HRH3 (0.52) | CHEK1CDK7PARP1HPGDHRH3 | |
| SCHEMBL4571045 | 0.77 | NR3C1 (0.54) | NR3C1CYP3A4 | |
| SCHEMBL6384914 | 0.76 | NR3C1 (0.56) | NR3C1CYP3A4 | |
| SCHEMBL291539 | 0.75 | NR3C1 (0.68) | NR3C1CYP3A4 | |
| SCHEMBL5798281 | 0.75 | NR3C1 (0.49) | NR3C1CYP3A4 | |
| SCHEMBL14319802 | 0.74 | EGFR (0.52) | CHEK1CDK7FGFR1SRCFGFR2 | |
| SCHEMBL5801704 | 0.73 | NR3C1 (0.60) | NR3C1CYP3A4 | |
| SCHEMBL5823680 | 0.73 | HRH4 (0.41) | CHEK1HPGDHRH3 | |
| SCHEMBL6383334 | 0.72 | NR3C1 (0.64) | NR3C1CYP3A4 | |
| SCHEMBL14286600 | 0.71 | CHEK1 (0.47) | CHEK1CDK7PARP1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101522187-A | Compositions and methods for treating, reducing, ameliorating, or alleviating posterior-segment ophthalmic diseases | BAUSCH & LOMB (US) | 2009-09-02 | — | — | CN | disclosed |
| CN-101522196-A | Treatment of infections and their sequelae with combined isolated glucocorticoid receptor agonists and anti-infective agents | BAUSCH & LOMB (US) | 2009-09-02 | — | — | CN | disclosed |