Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.90 |
| ▸ | GRM6 | O15303 | 2/20 | 0.90 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.90 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.90 |
| ▸ | GSR | P00390 | 2/20 | 0.90 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.90 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.90 |
| ▸ | GRM5 | P41594 | 1/20 | 0.90 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.90 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.90 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.90 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.90 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.90 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.90 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.90 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.90 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.90 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL5823746 | 1.00 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28236392 | 0.95 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL410241 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL17127348 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL1554237 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL5704264 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1330824 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1330484 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL248800 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL2201 | 0.95 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105665002-A | Method for regenerating deactivated titanium silicon molecular sieve catalyst | 中国天辰工程有限公司 | 2016-06-15 | — | — | CN | claimed |
| CN-104203841-A | Synergistic silica scale control | DOW GLOBAL TECHNOLOGIES INC | 2014-12-10 | — | — | CN | claimed |
| CN-103205317-B | Rheologically modified cleanser for kitchen heavy oily dirt, and preparation method thereof | YU WEN | 2014-11-12 | — | — | CN | claimed |
| CN-104135858-A | ANTI-MICROBIAL COMPOSITION | BYOTROL PLC | 2014-11-05 | — | — | CN | claimed |
| CN-104093812-A | Method of delaying crosslinking in well treatment operation | BAKER HUGHES INC | 2014-10-08 | — | — | CN | claimed |
| CN-104093394-A | Hair care composition | PROCTER & GAMBLE | 2014-10-08 | — | — | CN | claimed |
| CN-104031753-A | Detergency-improved tableware detergent composition with suspended particles | GUANGZHOU LIBY ENTPR CO LTD | 2014-09-10 | — | — | CN | claimed |
| CN-104010510-A | Formulations containing amino-/polyaminocarboxylates and organic phosphates, phosphonates or phosphites and their use in agriculture | BASF SE | 2014-08-27 | — | — | CN | claimed |
| CN-101254157-B | Preservative compositions | TAKASAGO PERFUMERY CO LTD | 2014-07-30 | — | — | CN | claimed |
| CN-103608315-A | Use of aminocarboxylates in agriculture | BASF SE | 2014-02-26 | — | — | CN | claimed |
| CN-101254157-A | Preservative compositions | TAKASAGO PERFUMERY CO LTD (JP) | 2008-09-03 | — | — | CN | claimed |
| CN-101043919-A | Surfactant-based composition | KITAKYUSHU FOUNDATION (JP) | 2007-09-26 | — | — | CN | claimed |
| CN-101018849-A | Cleaning formulations for dishcleaning machine containing hydrophobically modified polycarboxylate | BASF AG (DE) | 2007-08-15 | — | — | CN | claimed |
| CN-1211818-C | Electrolytic solution for electrolytic capacitor and electrolytic capacitor | RUBYCON CORP (JP) | 2005-07-20 | — | — | CN | claimed |
| CN-1530979-A | Electrolytic solution for electrolytic capacitor and electrolytic capcitor | ����̿����ʽ���� | 2004-09-22 | — | — | CN | claimed |
| CN-1529892-A | Electrolyte for driving electrolytic capacitor and electrolytic capacitor | 如碧空株式会社 | 2004-09-15 | — | — | CN | claimed |
| CN-1158683-C | Electrolytic capacitor | ����̿����ʽ���� | 2004-07-21 | — | — | CN | claimed |
| CN-1494723-A | Electrolytic capacitor and electrolyte for driving electrolytic capacitor | 如碧空株式会社 | 2004-05-05 | — | — | CN | claimed |
| CN-1277728-A | Electrolytic capacitor | RUBYCON CORP (JP) | 2000-12-20 | — | — | CN | claimed |
| CN-1275239-A | Electrolytic solution for electrolytic capacitor and electrolytic capacitor | RUBYCON CORP (JP) | 2000-11-29 | — | — | CN | claimed |