Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 13/20 | 0.58 |
| ▸ | KIT | P10721 | 5/20 | 0.58 |
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | TEK | Q02763 | 3/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | BLK | P51451 | 2/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15978893 | 0.90 | RET (0.62) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL5823912 | 0.89 | KDR (0.52) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL5802933 | 0.89 | AURKA (0.56) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL5804211 | 0.88 | AURKB (0.59) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL14985444 | 0.83 | RET (0.68) | KDRRETSRCPIK3CDABL1 | |
| SCHEMBL5801797 | 0.83 | AURKA (0.57) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL6437239 | 0.82 | KDR (0.66) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL5803692 | 0.81 | KDR (0.62) | AURKAAURKBIKBKEKDRKIT | |
| SCHEMBL14985435 | 0.80 | RET (0.73) | AURKAAURKBKDRKITFLT3 | |
| SCHEMBL6431567 | 0.80 | LCK (0.57) | AURKAAURKBIKBKEKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |