Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.52 |
| ▸ | FLT3 | P36888 | 9/20 | 0.52 |
| ▸ | KIT | P10721 | 7/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | RET | P07949 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | BLK | P51451 | 4/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 4/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.47 |
| ▸ | STK3 | Q13188 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FER | P16591 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823907 | 0.89 | AURKA (0.58) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL15978893 | 0.81 | RET (0.62) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL5804211 | 0.80 | AURKB (0.59) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL5802933 | 0.79 | AURKA (0.56) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL6437239 | 0.76 | KDR (0.66) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL5801797 | 0.75 | AURKA (0.57) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL3526559 | 0.73 | KDR (0.79) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL14985444 | 0.73 | RET (0.68) | KDRRETABL1 | |
| SCHEMBL5803692 | 0.73 | KDR (0.62) | KDRFLT3KITAURKAAURKB | |
| SCHEMBL6431567 | 0.72 | LCK (0.57) | KDRFLT3KITAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |