Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 13/20 | 0.59 |
| ▸ | FLT3 | P36888 | 4/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 7/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.49 |
| ▸ | ABL1 | P00519 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | PRKDC | P78527 | 5/20 | 0.49 |
| ▸ | HCK | P08631 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.49 |
| ▸ | MTOR | P42345 | 4/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15978893 | 0.93 | RET (0.62) | AURKBAURKAIKBKEKDRFLT3 | |
| SCHEMBL5802933 | 0.91 | AURKA (0.56) | AURKBAURKAIKBKEKDRFLT3 | |
| SCHEMBL5823907 | 0.88 | AURKA (0.58) | AURKBAURKAIKBKEKDRFLT3 | |
| SCHEMBL14985444 | 0.84 | RET (0.68) | KDRRETSRCPIK3CDABL1 | |
| SCHEMBL6437239 | 0.83 | KDR (0.66) | AURKBAURKAIKBKEKDRFLT3 | |
| SCHEMBL14985435 | 0.82 | RET (0.73) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL15978894 | 0.82 | RET (0.67) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL12120716 | 0.81 | AURKB (0.78) | AURKBAURKAIKBKEKDRFLT3 | |
| SCHEMBL5801797 | 0.81 | AURKA (0.57) | AURKBAURKAIKBKEKDRFLT3 | |
| SCHEMBL5823912 | 0.80 | KDR (0.52) | AURKBAURKAIKBKEKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| US-20050008640-A1 | Method of treating transplant rejection | ABBOTT LABORATORIES | 2005-01-13 | — | — | US | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | LCK, ZAP70, FYN | AURKB 1952/4885AURKA 2294/4885IKBKE 1020/4885 |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | AURKB 481/4885AURKA 443/4885IKBKE 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.