Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389831 | 0.87 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| Adp-597 SCHEMBL386884 | 0.82 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| Adp-597 SCHEMBL29645341 | 0.82 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL6066337 | 0.80 | GPR119 (0.58) | GPR119CYP2C9KCNH2 | |
| SCHEMBL387057 | 0.79 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389886 | 0.78 | GPR119 (0.89) | GPR119CYP2C9KCNH2 | |
| SCHEMBL1712505 | 0.78 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390024 | 0.77 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3246517 | 0.76 | GPR119 (0.80) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3252605 | 0.76 | GPR119 (0.80) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732562-A2 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006083491-A2 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |