Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387953 | 0.85 | GPR119 (0.77) | GPR119CYP2C9KCNH2 | |
| SCHEMBL290305 | 0.80 | GPR119 (0.45) | GPR119CYP2C9 | |
| SCHEMBL5823934 | 0.80 | GPR119 (0.77) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3164074 | 0.79 | GPR119 (0.61) | GPR119CYP2C9KCNH2 | |
| SCHEMBL6456096 | 0.76 | GPR119 (0.54) | GPR119CYP2C9KCNH2 | |
| SCHEMBL5133272 | 0.75 | GPR119 (0.60) | GPR119CYP2C9KCNH2 | |
| SCHEMBL1445594 | 0.74 | GPR119 (0.40) | GPR119CYP2C9 | |
| SCHEMBL1712505 | 0.73 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389215 | 0.73 | GPR119 (0.71) | GPR119CYP2C9KCNH2 | |
| SCHEMBL386714 | 0.72 | GPR119 (0.72) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-A1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007647-A1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |