Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL7375209 | 0.99 | ACE (0.38) | ACEDPP8DPP7DPP4DPP9 | |
| Proline SCHEMBL7374724 | 0.91 | DPP8 (0.37) | DPP8DPP7DPP4DPP9CXCR3 | |
| SCHEMBL3369068 | 0.87 | SMN1; SMN2 (0.41) | DPP8DPP7CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5348541 | 0.87 | SMN1; SMN2 (0.41) | DPP8DPP7CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5349213 | 0.87 | SMN1; SMN2 (0.41) | DPP8DPP7CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9022605 | 0.87 | SMN1; SMN2 (0.41) | DPP8DPP7CYP1A2CYP2C9CYP2C19 | |
| Proline SCHEMBL7378488 | 0.86 | DPP4 (0.43) | DPP8DPP7DPP4DPP9CXCR3 | |
| SCHEMBL7951097 | 0.79 | ACE (0.41) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL3373748 | 0.78 | ANPEP (0.42) | DPP8DPP7DPP4DPP9CYP1A2 | |
| SCHEMBL5353931 | 0.78 | ANPEP (0.42) | DPP8DPP7DPP4DPP9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006022001-A | METHOD FOR PRODUCING LICINOPRIL DIHYDRATE | SHIONOGI & CO LTD | 2006-01-26 | — | — | JP | disclosed |