Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | CTSC | P53634 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266809 | 0.88 | DPP8 (0.42) | DPP4DPP7DPP8DPP9CTSC | |
| SCHEMBL7275820 | 0.88 | DPP8 (0.42) | DPP4DPP7DPP8DPP9CTSC | |
| Proline SCHEMBL7374724 | 0.88 | DPP8 (0.37) | DPP4DPP7DPP8DPP9CTSC | |
| Proline SCHEMBL5823940 | 0.86 | ACE (0.38) | DPP4DPP7DPP8DPP9CTSC | |
| Proline SCHEMBL7375209 | 0.85 | ACE (0.38) | DPP4DPP7DPP8DPP9CXCR3 | |
| SCHEMBL7266839 | 0.78 | DPP4 (0.53) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL5353931 | 0.74 | ANPEP (0.42) | DPP4DPP7DPP8DPP9ANPEP | |
| SCHEMBL3373748 | 0.74 | ANPEP (0.42) | DPP4DPP7DPP8DPP9ANPEP | |
| SCHEMBL7276985 | 0.73 | ANPEP (0.41) | DPP4DPP7DPP8DPP9ANPEP | |
| SCHEMBL7951097 | 0.72 | ACE (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336368-A2 | N2-(1-carboxy-3-phenylpropyl)-L-lysine derivative and process of producing lysinopril using the compound | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-10-11 | — | — | EP | disclosed |