Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6547467 | 0.97 | KDM4E (0.50) | KDM4ESMN1; SMN2HPGDCYP1A2PTGDR2 | |
| SCHEMBL11280088 | 0.81 | KDM4E (0.58) | KDM4ESMN1; SMN2HPGDCYP1A2POLB | |
| SCHEMBL5762947 | 0.75 | KDM4E (0.62) | KDM4ESMN1; SMN2HPGDCYP1A2POLB | |
| SCHEMBL27653921 | 0.75 | HPGD (0.58) | KDM4ESMN1; SMN2HPGDCYP1A2POLB | |
| SCHEMBL11994175 | 0.74 | KDM4E (0.53) | KDM4ESMN1; SMN2HPGDCYP1A2ALDH1A1 | |
| SCHEMBL5820644 | 0.74 | EGFR (0.53) | NR4A2ALDH1A1 | |
| SCHEMBL4879884 | 0.72 | KDM4E (0.59) | KDM4ESMN1; SMN2HPGDCYP1A2POLB | |
| SCHEMBL7601774 | 0.71 | HPGD (0.68) | KDM4ESMN1; SMN2HPGDCYP1A2POLB | |
| SCHEMBL6493957 | 0.71 | ADORA3 (0.55) | KDM4ESMN1; SMN2HPGDCYP1A2ALDH1A1 | |
| SCHEMBL27872988 | 0.70 | KDM4E (0.45) | KDM4ESMN1; SMN2HPGDCYP1A2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |