Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823944 | 0.97 | KDM4E (0.53) | KDM4EHPGDSMN1; SMN2PTGDR2LMNA | |
| SCHEMBL11280088 | 0.79 | KDM4E (0.58) | KDM4EHPGDSMN1; SMN2LMNATSHR | |
| SCHEMBL4879884 | 0.76 | KDM4E (0.59) | KDM4EHPGDSMN1; SMN2GAATSHR | |
| SCHEMBL27653921 | 0.72 | HPGD (0.58) | KDM4EHPGDSMN1; SMN2GAATSHR | |
| SCHEMBL5762947 | 0.72 | KDM4E (0.62) | KDM4EHPGDSMN1; SMN2LMNAGAA | |
| SCHEMBL11994175 | 0.72 | KDM4E (0.53) | KDM4EHPGDSMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL5820644 | 0.72 | EGFR (0.53) | PTGS1NR4A2ALDH1A1 | |
| SCHEMBL7601774 | 0.69 | HPGD (0.68) | KDM4EHPGDSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL6493957 | 0.69 | ADORA3 (0.55) | KDM4EHPGDSMN1; SMN2LMNAGAA | |
| SCHEMBL27872988 | 0.68 | KDM4E (0.45) | KDM4EHPGDSMN1; SMN2PTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748315-B1 | USE OF IMIDAZOLE DERIVATIVES FOR TREATING DISORDERS INVOLVING ANGIOTENSIN RECEPTORS AT1 AND AT2, THESE PRODUCTS, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2004-01-07 | — | — | EP | claimed |
| EP-0748314-B1 | TETRASUBSTITUTED IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING THE SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AVENTIS PHARMA SA (FR) | 2002-05-15 | — | — | EP | claimed |
| US-5811445-A | ANGIOTENSIN II INHIBITORS | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |
| US-5807878-A | CARDIOVASCULAR DISORDERS | Uclaf, Roussel (FR) | 1998-09-15 | — | — | US | disclosed |