Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813523 | 0.88 | P2RX7 (0.65) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL5917600 | 0.87 | P2RX7 (0.64) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL5814820 | 0.79 | P2RX7 (0.54) | P2RX7KMT2AALDH1A1GRM2 | |
| SCHEMBL5815858 | 0.78 | P2RX7 (0.81) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL5816280 | 0.77 | P2RX7 (1.00) | P2RX7TRPA1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL5815057 | 0.77 | P2RX7 (0.74) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL6357960 | 0.77 | P2RX7 (0.65) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL16872261 | 0.76 | P2RX7 (0.60) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL5810224 | 0.76 | P2RX7 (0.63) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 | |
| SCHEMBL6361627 | 0.76 | P2RX7 (0.60) | P2RX7KMT2AALDH1A1TRPA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006086229-A1 | THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2006-08-17 | — | — | WO | disclosed |