Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5824231 | 0.79 | P2RX7 (0.63) | P2RX7KMT2AALDH1A1GRM2 | |
| SCHEMBL5815309 | 0.76 | P2RX7 (0.71) | P2RX7KMT2AALDH1A1LMNAHTT | |
| SCHEMBL4403732 | 0.75 | P2RX7 (0.81) | P2RX7KMT2AALDH1A1LMNAHDAC6 | |
| SCHEMBL6362505 | 0.75 | P2RX7 (0.70) | P2RX7KMT2AALDH1A1LMNAHDAC6 | |
| SCHEMBL6357793 | 0.75 | P2RX7 (0.70) | P2RX7KMT2AALDH1A1LMNAHDAC6 | |
| SCHEMBL5813523 | 0.75 | P2RX7 (0.65) | P2RX7KMT2AALDH1A1LMNAHDAC6 | |
| SCHEMBL5917600 | 0.74 | P2RX7 (0.64) | P2RX7KMT2AALDH1A1LMNA | |
| SCHEMBL5815339 | 0.74 | P2RX7 (0.57) | P2RX7KMT2AALDH1A1LMNAHDAC6 | |
| SCHEMBL994214 | 0.73 | LMNA (0.57) | P2RX7KMT2AALDH1A1LMNAGRM2 | |
| SCHEMBL950306 | 0.73 | LMNA (0.57) | P2RX7KMT2AALDH1A1LMNAHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | ABBOTT LABORATORIES | 2006-09-21 | — | — | US | claimed |
| WO-2006086229-A1 | THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2006-08-17 | — | — | WO | claimed |
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | ABBOTT LABORATORIES | 2006-09-21 | — | — | US | disclosed |
| WO-2006086229-A1 | THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211739-A1 | Use of selective P2X7 receptor antagonists | P2RX1, P2RX3, P2RX7 | P2RX7 3/4885KMT2A 3534/4885ALDH1A1 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.