SCHEMBL5824323

SCHEMBL5824323

C=C(C)C(=O)NCC(O)OCC

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.35
TGFBR1 P36897 1/20 0.34
ALDH1A1 P00352 1/20 0.31
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17784307 0.83 EPHX1 (0.42) THRBTGFBR1ALDH1A1MGAMGAA
SCHEMBL20589431 0.81 TGFBR1 (0.32) TGFBR1
SCHEMBL3738357 0.76 TGFBR1 (0.41) TGFBR1ALDH1A1
SCHEMBL97375 0.76 TGFBR1 (0.41) TGFBR1ALDH1A1
SCHEMBL14931 0.75 TGFBR1 (0.37) THRBTGFBR1ALDH1A1
SCHEMBL5690855 0.74 TSHR (0.43) ALDH1A1
SCHEMBL12642676 0.74 TGFBR1 (0.39) TGFBR1ALDH1A1
SCHEMBL9759569 0.74 TGFBR1 (0.39) TGFBR1ALDH1A1
SCHEMBL16097 0.74 TGFBR1 (0.39) TGFBR1ALDH1A1
SCHEMBL9577882 0.73 TGFBR1 (0.44) THRBTGFBR1ALDH1A1MGAMGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7060776-B2 Monomers useful in the preparation of separation matrices GE HEALTHCARE BIO-SCIENCES AB (SE) 2006-06-13 US disclosed
EP-1101101-A4 METHOD FOR PRODUCING HYDROPHILIC MONOMERS AND USES THEREOF BIOWHITTAKER MOLUCULAR APPLIC (US) 2005-10-19 EP disclosed
US-20050113539-A1 Crosslinked, water insoluble matrix; electrophoresis membranes GE HEALTHCARE BIO-SCIENCES AB (SE) 2005-05-26 US disclosed
WO-2003055923-A1 NOVEL MONOMERS USEFUL IN THE PREPARATION OF SEPARATION MATRICES AMERSHAM BIOSCIENCES AB (SE) 2003-07-10 WO disclosed
US-6464850-B1 CAPILLARY AND MICROCHANNEL ELECTROPHORESIS; HYDROLYTICALLY STABLE,HIGH RESOLUTION; HOMO OR COPOLYMER OF N-(2-HYDROXY ETHYL)ACRYLAMIDE, N-(2-HYDROXYETHYL) METHACRYLAMIDE, N,N-DI(HYDROXYALKYL)ACRYLAMIDE; SUPPRESSES ELECTROENDOOSMOSIS BIOWHITTAKER MOLECULAR APPLICATIONS, INC. 2002-10-15 US disclosed
EP-1101101-A1 METHOD FOR PRODUCING HYDROPHILIC MONOMERS AND USES THEREOF Biowhittaker Molucular Applications, Inc. (US) 2001-05-23 EP disclosed
US-6117293-A MONOMERS AND CROSSLINKER FOR PREPARING AN ELECTROPHORETIC GEL COMPRISES 75 WEIGHT % OR MORE OF HYDROPHILLIC MONOMER SELECTED FROM N-HYDROXYETHYL(METH)ACRYLAMIDE OR N,N-DIHYDROXYALKYL(METH)ACRYLAMIDE BIOWHITTAKER MOLECULAR APPLICATIONS, INC. (US) 2000-09-12 US disclosed
WO-2000007002-A1 METHOD FOR PRODUCING HYDROPHILIC MONOMERS AND USES THEREOF BIOWHITTAKER MOLECULAR APPLICATIONS, INC. (US) 2000-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113539-A1 Crosslinked, water insoluble matrix; electrophoresis membranes H1-0, H1-4, H1-2 THRB 4077/4885TGFBR1 633/4885ALDH1A1 1309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.