Sugi Predict

Sugi Predict / Compounds / SCHEMBL5824847

SCHEMBL5824847

SCHEMBL5824847

COc1cc2nccc(Oc3ccc(NC(=O)NCCN(C(C)C)C(C)C)c([N+](=O)[O-])c3)c2cc1OC

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDGFRA P16234 14/20 0.59
▸ KDR P35968 14/20 0.59
▸ KIT P10721 3/20 0.51
▸ AXL P30530 2/20 0.51
▸ FGFR2 P21802 1/20 0.51
▸ MET P08581 6/20 0.50
▸ RIPK2 O43353 2/20 0.50
▸ STK10 O94804 2/20 0.50
▸ ABL1 P00519 2/20 0.50
▸ LCK P06239 2/20 0.50
▸ LYN P07948 2/20 0.50
▸ RET P07949 2/20 0.50
▸ PDGFRB P09619 2/20 0.50
▸ SRC P12931 2/20 0.50
▸ FLT1 P17948 2/20 0.50
▸ FLT4 P35916 2/20 0.50
▸ FLT3 P36888 2/20 0.50
▸ ABL2 P42684 2/20 0.50
▸ FRK P42685 2/20 0.50
▸ DDR1 Q08345 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5824384 0.90 PDGFRA (0.60) PDGFRAKDRKITAXLFGFR2
SCHEMBL5824347 0.89 PDGFRA (0.61) PDGFRAKDRKITAXLFGFR2
SCHEMBL5205225 0.88 KDR (0.65) PDGFRAKDRKITAXLFGFR2
SCHEMBL5825381 0.88 KDR (0.59) PDGFRAKDRKITPDGFRBFLT1
SCHEMBL4469272 0.86 PDGFRA (0.62) PDGFRAKDRKITAXLFGFR2
SCHEMBL5824778 0.84 PDGFRA (0.68) PDGFRAKDRMET
SCHEMBL5825041 0.83 KDR (0.55) PDGFRAKDRKITAXLFGFR2
SCHEMBL5824645 0.83 KDR (0.58) PDGFRAKDRKITAXLFGFR2
SCHEMBL5825708 0.82 MET (0.50) PDGFRAKDRKITAXLFGFR2
SCHEMBL5825543 0.80 SRC (0.49) PDGFRAKDRKITAXLFGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7135466-B2 Quinoline and quinazoline derivatives and drugs containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-11-14 — — US claimed
US-7135466-B2 Quinoline and quinazoline derivatives and drugs containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-11-14 — — US disclosed
US-20060211717-A1 Quinoline and quinazoline derivatives and drugs containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-21 — — US disclosed
US-20040132727-A1 Quinoline and quinazoline derivatives and drugs containing the same KIRIN HOLDINGS KABUSHIKI KAISHA (JP) 2004-07-08 — — US disclosed
EP-1243582-A1 QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2002-09-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211717-A1 Quinoline and quinazoline derivatives and drugs containing the same PDGFRA, PDGFRB, PDGFA PDGFRA 1/4885KDR 4/4885KIT 401/4885
US-20040132727-A1 Quinoline and quinazoline derivatives and drugs containing the same PDGFRA, PDGFRB, PDGFA PDGFRA 1/4885KDR 5/4885KIT 499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.