Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.55 |
| ▸ | FLT4 | P35916 | 6/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIF5B | P33176 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5824555 | 0.97 | PDGFRB (0.56) | PDGFRBFLT4CSF1RFLT3KDR | |
| SCHEMBL5824935 | 0.94 | PDGFRB (0.57) | PDGFRBFLT4CSF1RFLT3KDR | |
| SCHEMBL5825239 | 0.85 | PDGFRA (0.54) | PDGFRBKDREGFR | |
| SCHEMBL5824704 | 0.83 | KDR (0.53) | PDGFRBFLT4CSF1RFLT3KDR | |
| SCHEMBL5825626 | 0.82 | PDGFRA (0.55) | PDGFRBKDREGFR | |
| SCHEMBL20229657 | 0.82 | KDR (0.74) | PDGFRBFLT4CSF1RFLT3KDR | |
| SCHEMBL5825352 | 0.80 | PDGFRB (0.74) | PDGFRBFLT4CSF1RFLT3KDR | |
| SCHEMBL5825028 | 0.80 | KDR (0.54) | PDGFRBFLT4CSF1RFLT3KDR | |
| SCHEMBL5824639 | 0.79 | PDGFRA (0.56) | PDGFRBKDREGFR | |
| SCHEMBL8807826 | 0.77 | PDGFRB (0.62) | PDGFRBFLT4CSF1RFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | PDGFRB 2/4885FLT4 6/4885CSF1R 189/4885 |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | PDGFRB 2/4885FLT4 4/4885CSF1R 293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.