Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.74 |
| ▸ | FLT4 | P35916 | 7/20 | 0.74 |
| ▸ | FLT3 | P36888 | 4/20 | 0.74 |
| ▸ | CSF1R | P07333 | 4/20 | 0.74 |
| ▸ | KDR | P35968 | 8/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | KIF5B | P33176 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5825666 | 0.87 | CSF1R (0.62) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL5825606 | 0.86 | TRPA1 (0.64) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL5824648 | 0.86 | KDR (0.72) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL18158553 | 0.82 | KDR (0.70) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL5825516 | 0.82 | FGFR2 (0.61) | PDGFRBKDREGFRPDGFRA | |
| SCHEMBL13680204 | 0.82 | KDR (0.73) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL15463614 | 0.82 | KDR (0.73) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL5824555 | 0.81 | PDGFRB (0.56) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL15607578 | 0.81 | PDGFRB (0.77) | PDGFRBFLT4FLT3CSF1RKDR | |
| SCHEMBL5824899 | 0.80 | PDGFRB (0.55) | PDGFRBFLT4FLT3CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | PDGFRB 2/4885FLT4 6/4885FLT3 68/4885 |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | PDGFRB 2/4885FLT4 4/4885FLT3 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.