Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582811 | 0.92 | HSP90AB1 (0.61) | HSP90AB1MAPK8GRM2HDAC3HDAC4 | |
| SCHEMBL582923 | 0.84 | HSP90AB1 (0.53) | HSP90AB1GRM2ACHEGSK3AGSK3B | |
| SCHEMBL2120980 | 0.83 | MAPK14 (0.48) | HSP90AB1ALDH1A1ALDH2ALDH3A1ACHE | |
| SCHEMBL581516 | 0.81 | HSP90AB1 (0.52) | HSP90AB1MAPK8GRM2HDAC3HDAC4 | |
| SCHEMBL20786928 | 0.81 | HDAC3 (0.47) | HSP90AB1GRM2HDAC3HDAC1HDAC6 | |
| SCHEMBL20786901 | 0.81 | TNF (0.41) | HSP90AB1GRM2HDAC3HDAC1HDAC6 | |
| SCHEMBL1725380 | 0.81 | TNF (0.39) | HSP90AB1GRM2HDAC3HDAC1HDAC6 | |
| SCHEMBL20808710 | 0.77 | PSMB1 (0.41) | HSP90AB1GRM2GSK3BPSMB1PSMB5 | |
| SCHEMBL20809182 | 0.77 | PSMB1 (0.41) | HSP90AB1GRM2ALDH1A1PSMB1PSMB5 | |
| SCHEMBL6923560 | 0.77 | GRM2 (0.55) | HSP90AB1GRM2HDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2416660-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | Infinity Pharmaceuticals, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118155-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |