Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | COMT | P21964 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582560 | 0.84 | HSP90AB1 (0.53) | HSP90AB1COMTTNFPSMB1PSMB5 | |
| SCHEMBL29283811 | 0.82 | HSP90AB1 (0.69) | HSP90AB1CASRGRM2ACHE | |
| SCHEMBL31006547 | 0.80 | HSP90AB1 (0.67) | HSP90AB1CASRGRM2NLRP3 | |
| SCHEMBL29283813 | 0.80 | HSP90AB1 (0.67) | HSP90AB1CASRGRM2NLRP3 | |
| SCHEMBL29283806 | 0.76 | HSP90AB1 (0.76) | HSP90AB1PSMB2CASRGRM2ACHE | |
| SCHEMBL31006527 | 0.76 | HSP90AB1 (0.76) | HSP90AB1PSMB2CASRGRM2ACHE | |
| SCHEMBL582811 | 0.76 | HSP90AB1 (0.61) | HSP90AB1GRM2ACHE | |
| SCHEMBL2627972 | 0.75 | HSP90AB1 (0.58) | HSP90AB1TNFPSMB1PSMB5PSMB2 | |
| SCHEMBL29283851 | 0.75 | HSP90AB1 (0.64) | HSP90AB1CASRGRM2 | |
| SCHEMBL24542761 | 0.74 | HTR1A (0.49) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2416660-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | Infinity Pharmaceuticals, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118155-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE | INFINITY PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |