Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 6/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5522553 | 1.00 | POLQ (0.36) | POLQRIPK1POLBCCR2RORC | |
| SCHEMBL583527 | 1.00 | POLQ (0.36) | POLQRIPK1POLBCCR2RORC | |
| SCHEMBL13255843 | 0.94 | RIPK1 (0.38) | POLQRIPK1POLBCCR2RORC | |
| SCHEMBL5510049 | 0.85 | POLB (0.38) | POLBCCR2KMT2ADHODHTACR1 | |
| SCHEMBL5518614 | 0.85 | POLB (0.38) | POLBCCR2KMT2ADHODHTACR1 | |
| SCHEMBL5513050 | 0.85 | POLB (0.38) | POLBCCR2KMT2ADHODHTACR1 | |
| SCHEMBL5521185 | 0.83 | KMT2A (0.44) | RIPK1POLBKMT2A | |
| SCHEMBL582894 | 0.83 | KMT2A (0.44) | RIPK1POLBKMT2A | |
| SCHEMBL582690 | 0.83 | KMT2A (0.44) | RIPK1POLBKMT2A | |
| SCHEMBL4308440 | 0.82 | CETP (0.36) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755572-B1 | N- (2-BENZYL) -2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2012-02-15 | — | — | EP | claimed |
| US-7268153-B2 | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators | MERCK & CO., INC. (US) | 2007-09-11 | — | — | US | claimed |