Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582894 | 1.00 | KMT2A (0.44) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL5521185 | 1.00 | KMT2A (0.44) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL582744 | 0.94 | CETP (0.44) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL582743 | 0.94 | CETP (0.44) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL5517353 | 0.93 | KMT2A (0.46) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL582826 | 0.93 | KMT2A (0.46) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL5513992 | 0.93 | KMT2A (0.46) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL582742 | 0.84 | POLB (0.44) | KMT2ALMNAL3MBTL1NPSR1POLB | |
| SCHEMBL582587 | 0.83 | POLQ (0.36) | KMT2APOLBRIPK1 | |
| SCHEMBL5522553 | 0.83 | POLQ (0.36) | KMT2APOLBRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755572-B1 | N- (2-BENZYL) -2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2012-02-15 | — | — | EP | claimed |
| US-7268153-B2 | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators | MERCK & CO., INC. (US) | 2007-09-11 | — | — | US | claimed |