Sugi Predict

Sugi Predict / Compounds / SCHEMBL58274

SCHEMBL58274

SCHEMBL58274

Nc1ncnn2cccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MAP4K4 O95819 8/20 1.00
▸ PIK3CA P42336 1/20 0.47
▸ EGFR P00533 3/20 0.46
▸ PDE10A Q9Y233 1/20 0.41
▸ KDR P35968 2/20 0.40
▸ IRAK4 Q9NWZ3 1/20 0.40
▸ LIMK1 P53667 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ KIT P10721 1/20 0.35
▸ JAK2 O60674 1/20 0.34
▸ SMPD3 Q9NY59 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL15019896 0.98 MAP4K4 (0.96) MAP4K4PIK3CAEGFRPDE10AKDR
Hydrochloric Acid SCHEMBL30590600 0.98 MAP4K4 (0.96) MAP4K4PIK3CAEGFRPDE10AKDR
Iodide SCHEMBL30111106 0.98 MAP4K4 (0.96) MAP4K4PIK3CAEGFRPDE10AKDR
SCHEMBL12471777 0.77 MAP4K4 (0.62) MAP4K4PIK3CAEGFRPDE10AKDR
SCHEMBL17130415 0.77 MAP4K4 (0.62) MAP4K4PIK3CAEGFRPDE10AKDR
SCHEMBL398829 0.75 MAP4K4 (0.60) MAP4K4PIK3CAPDE10AKDM4EALDH1A1
SCHEMBL14044627 0.75 MAP4K4 (0.60) MAP4K4PIK3CAEGFRPDE10AKDR
SCHEMBL864036 0.75 MAP4K4 (0.60) MAP4K4PIK3CAEGFRPDE10AKDR
SCHEMBL867042 0.75 MAP4K4 (0.60) MAP4K4PIK3CAEGFRPDE10AKDR
SCHEMBL4818798 0.75 MAP4K4 (0.60) MAP4K4PIK3CAEGFRPDE10AKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 515 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 — — US claimed
CN-120025352-A Condensed heterocyclic compound, pharmaceutical composition and application thereof 北京康辰药业股份有限公司 2025-05-23 — — CN claimed
US-20250115610-A1 PROCESS FOR THE CATALYTIC GLYCOSYLATION OF ARENES STUDIENGESELLSCHAFT KOHLE GGMBH (DE) 2025-04-10 — — US claimed
CN-119654311-A Carbobicyclic nucleosides for treatment of viral infections 香港中文大学 2025-03-18 — — CN claimed
EP-4508037-A1 CARBOBICYCLIC NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTION The Chinese University of Hong Kong (HK) 2025-02-19 — — EP claimed
EP-4380938-A1 PROCESS FOR THE CATALYTIC GLYCOSYLATION OF ARENES Studiengesellschaft Kohle gGmbH (DE) 2024-06-12 — — EP claimed
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2024-05-02 — — US claimed
CN-117836298-A Catalytic glycosylation process for aromatic hydrocarbons 科勒研究非盈利有限责任公司 2024-04-05 — — CN claimed
CN-117659397-A Preparation method and application of polyimide-based COF 山东精工电子科技股份有限公司 2024-03-08 — — CN claimed
CN-115124539-B Preparation method of 7-iodopyrrolo [2,1-F ] [1,2,4] triazine-4-amine 河南豫辰药业股份有限公司 2024-02-27 — — CN claimed
CN-111423443-A Preparation method of 4-amino-7-iodopyrrolo [2,1-f ] [1,2,4] triazine 广州科锐特生物科技有限公司 2020-07-17 — — CN claimed
CN-110845502-A Preparation method of 7-bromopyrrolo [2,1-f ] [1,2,4] thiazine-4-amine 成都傲飞生物化学品有限责任公司 2020-02-28 — — CN claimed
CN-107864625-A Combination product containing 2,3 substituted glyoxalidine simultaneously [1,2 c] quinazoline 拜耳制药股份公司 2018-03-30 — — CN claimed
US-9475815-B2 Substituted benzothienyl-pyrrolotriazines and uses thereof BAYER INTELLETUAL PROPERTY GMBH (DE) 2016-10-25 — — US claimed
EP-2791140-B1 DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS Bayer Pharma AG (DE) 2016-06-15 — — EP claimed
EP-2817311-B1 SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF BAYER IP GMBH (DE) 2016-04-06 — — EP claimed
US-20150031676-A1 SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-01-29 — — US claimed
EP-2817311-A1 SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF Bayer Intellectual Property GmbH (DE) 2014-12-31 — — EP claimed
CN-104245700-A Disubstituted benzothienyl-pyrrolotriazines and their use as fgfr kinase inhibitors Bayer Pharma AG 2014-12-24 — — CN claimed
WO-2013124316-A1 SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-08-29 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 MAP4K4 4773/4885PIK3CA 3826/4885EGFR 935/4885
US-20150031676-A1 SUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND USES THEREOF STK25, JAK2, PTK2B MAP4K4 34/4885PIK3CA 376/4885EGFR 591/4885
US-20250115610-A1 PROCESS FOR THE CATALYTIC GLYCOSYLATION OF ARENES GALE, UGT1A4, CYP3A4 MAP4K4 510/4885PIK3CA 1117/4885EGFR 3059/4885
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS SLC10A1, HAVCR2, HDGF MAP4K4 2918/4885PIK3CA 3543/4885EGFR 2433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.