Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.49 |
| ▸ | HTR1A | P08908 | 11/20 | 0.49 |
| ▸ | HTR2A | P28223 | 11/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827507 | 0.80 | DRD2 (0.51) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL5363297 | 0.76 | DRD2 (0.47) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL5369461 | 0.74 | DRD2 (0.51) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL5373862 | 0.71 | HTR1A (0.61) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL5366536 | 0.70 | DRD2 (0.48) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL15546792 | 0.70 | DRD2 (0.54) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL22844470 | 0.70 | HTR1A (0.57) | DRD2HTR1AHTR2ASLC6A4KCNH2 | |
| SCHEMBL15601661 | 0.70 | DRD2 (0.62) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL15534212 | 0.70 | HTR1A (0.59) | DRD2HTR1AHTR2ASLC6A4DRD3 | |
| SCHEMBL17471492 | 0.70 | DRD2 (0.59) | DRD2HTR1AHTR2ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660497-A1 | [ 1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019215-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-03 | — | — | WO | disclosed |