Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827652 | 1.00 | PDE10A (0.47) | PDE10AKITBRAFRAF1PDE3B | |
| SCHEMBL5828583 | 0.83 | RET (0.41) | BRAFRAF1KDREGFR | |
| SCHEMBL5828593 | 0.83 | RET (0.41) | BRAFRAF1KDREGFR | |
| SCHEMBL5829126 | 0.80 | KDR (0.51) | KITERBB2EPHA2KDREPHB4 | |
| SCHEMBL5829124 | 0.80 | KDR (0.51) | KITERBB2EPHA2KDREPHB4 | |
| SCHEMBL5827935 | 0.78 | EGFR (0.50) | KITKDREGFR | |
| SCHEMBL5827933 | 0.78 | EGFR (0.50) | KITKDREGFR | |
| SCHEMBL5828492 | 0.78 | RET (0.41) | BRAFRAF1KDREGFR | |
| SCHEMBL5828499 | 0.78 | RET (0.41) | BRAFRAF1KDREGFR | |
| SCHEMBL5828485 | 0.78 | EGFR (0.53) | KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |