Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 14/20 | 0.54 |
| ▸ | KDR | P35968 | 13/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828061 | 1.00 | EPHA2 (0.54) | EPHA2KDREPHB4ERBB2DRD4 | |
| SCHEMBL6984999 | 0.89 | EPHA2 (0.59) | EPHA2KDREPHB4ERBB2 | |
| SCHEMBL5828782 | 0.85 | EPHA2 (0.38) | EPHA2KDREPHB4ERBB2KIT | |
| SCHEMBL5828784 | 0.85 | EPHA2 (0.38) | EPHA2KDREPHB4ERBB2KIT | |
| SCHEMBL5829043 | 0.83 | EPHA2 (0.52) | EPHA2KDREPHB4KIT | |
| SCHEMBL5829045 | 0.83 | EPHA2 (0.52) | EPHA2KDREPHB4KIT | |
| SCHEMBL4688686 | 0.80 | EPHA2 (0.67) | EPHA2KDREPHB4ERBB2DRD4 | |
| SCHEMBL5828594 | 0.79 | EPHA2 (0.36) | EPHA2KDREPHB4 | |
| SCHEMBL5828595 | 0.79 | EPHA2 (0.36) | EPHA2KDREPHB4 | |
| SCHEMBL5828492 | 0.77 | RET (0.41) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |