Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 13/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KIF5B | P33176 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828594 | 1.00 | EPHA2 (0.36) | EPHA2RETMAPK14KIF5BEGFR | |
| SCHEMBL6985534 | 0.88 | EPHA2 (0.40) | EPHA2RETMAPK14KIF5BEGFR | |
| SCHEMBL5829043 | 0.85 | EPHA2 (0.52) | EPHA2KDREPHB4 | |
| SCHEMBL5829045 | 0.85 | EPHA2 (0.52) | EPHA2KDREPHB4 | |
| SCHEMBL5828784 | 0.82 | EPHA2 (0.38) | EPHA2MAPK14KDREPHB4 | |
| SCHEMBL5828782 | 0.82 | EPHA2 (0.38) | EPHA2MAPK14KDREPHB4 | |
| SCHEMBL5828499 | 0.80 | RET (0.41) | RETKIF5BEGFRKDR | |
| SCHEMBL5828492 | 0.80 | RET (0.41) | RETKIF5BEGFRKDR | |
| SCHEMBL5828061 | 0.79 | EPHA2 (0.54) | EPHA2KDREPHB4 | |
| SCHEMBL5828059 | 0.79 | EPHA2 (0.54) | EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |