Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 1.00 |
| ▸ | CCNE2 | O96020 | 13/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 13/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.66 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | CDK1 | P06493 | 4/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | CDK7 | P50613 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | CCNH | P51946 | 1/20 | 0.57 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3680206 | 0.88 | CCNE2 (1.00) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL5827987 | 0.85 | CDK2 (0.75) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL5827985 | 0.85 | CDK2 (0.73) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL5828204 | 0.83 | CCNE2 (0.71) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL3678763 | 0.83 | CCNE2 (1.00) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL2364042 | 0.78 | CDK1 (0.87) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL4277404 | 0.77 | CDK1 (1.00) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL3681929 | 0.76 | CCNE2 (0.77) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL14071580 | 0.76 | CDK2 (0.85) | CDK2CCNE2CCNE1CDK5CDK5R1 | |
| SCHEMBL19112101 | 0.75 | HTT (0.78) | CDK2CCNE2CCNE1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020035252-A1 | Purine inhibitors of cyclin dependent kinase 2 & IkBa | LUM ROBERT T (US) | 2002-03-21 | — | — | US | claimed |
| EP-1150982-A1 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND I$g(k)-A$g(a) | CV THERAPEUTICS, INC. (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2000044750-A1 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a) | CV THERAPEUTICS, INC. (US) | 2000-08-03 | — | — | WO | claimed |
| US-7109330-B2 | Purine inhibitors of cyclin dependent kinase 2 and IκB-α | CV THERAPEUTICS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | LUM ROBERT T (US) | 2005-04-14 | — | — | US | disclosed |
| US-20020035252-A1 | Purine inhibitors of cyclin dependent kinase 2 & IkBa | LUM ROBERT T (US) | 2002-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | IKBKB, NFKB1, CDK4 | CDK2 5/4885CCNE2 65/4885CCNE1 51/4885 |
| US-20020035252-A1 | Purine inhibitors of cyclin dependent kinase 2 & IkBa | AURKB, CDKN1A, IKBKB | CDK2 8/4885CCNE2 202/4885CCNE1 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.