Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 10/20 | 0.40 |
| ▸ | CA2 | P00918 | 10/20 | 0.40 |
| ▸ | CA9 | Q16790 | 10/20 | 0.40 |
| ▸ | CA12 | O43570 | 8/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828426 | 0.95 | PTGS2 (0.43) | PTGS2LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828083 | 0.90 | PTGS2 (0.44) | PTGS2LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828685 | 0.86 | PTGS2 (0.43) | PTGS2LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828553 | 0.85 | PTGS2 (0.47) | PTGS2LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828047 | 0.83 | LMNA (0.45) | PTGS2LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828429 | 0.81 | LMNA (0.41) | PTGS2LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL6197547 | 0.81 | LMNA (0.47) | LMNATHRBSMN1; SMN2HIF1ACA1 | |
| SCHEMBL5828932 | 0.80 | LMNA (0.45) | LMNATHRBSMN1; SMN2HIF1ACA1 | |
| SCHEMBL5827541 | 0.79 | LMNA (0.47) | LMNATHRBSMN1; SMN2HIF1ACA1 | |
| SCHEMBL6081330 | 0.76 | LMNA (0.42) | LMNATHRBSMN1; SMN2HIF1ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001906-B2 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2006-02-21 | — | — | US | disclosed |
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | PYM1, PNPO, IDO1 | PTGS2 557/4885LMNA 4488/4885THRB 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.