Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 3/20 | 0.41 |
| ▸ | PRKACG | P22612 | 3/20 | 0.41 |
| ▸ | PRKACB | P22694 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831573 | 0.91 | SIRT2 (0.59) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL5828628 | 0.86 | PIM1 (0.48) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL7822743 | 0.80 | CAMK2D (0.44) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL6081382 | 0.79 | CREBBP (0.45) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL5828665 | 0.77 | PIM1 (0.48) | PIM1CCNT1CDK9SIRT2MARK3 | |
| SCHEMBL28101324 | 0.76 | CAMK2D (0.48) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL28671383 | 0.74 | SIRT2 (0.56) | PIM1CCNT1CDK9SIRT2MARK3 | |
| SCHEMBL7826797 | 0.72 | PRKCA (0.52) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL6575546 | 0.72 | PIM1 (0.53) | PIM1CCNT1CDK9SIRT2SIRT1 | |
| SCHEMBL28655133 | 0.71 | BRD4 (0.42) | PIM1CCNT1CDK9SIRT2MARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001906-B2 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2006-02-21 | — | — | US | disclosed |
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | PYM1, PNPO, IDO1 | PIM1 1680/4885CCNT1 354/4885CDK9 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.